Digitalis-like activity in human plasma
نویسندگان
چکیده
منابع مشابه
Endogenous digitalis-like factors in human milk.
We measured the concentration of endogenous digitalis-like factors (EDLFs) in milk or colostrum of women during nursing on different days after delivery. EDLF concentrations were assayed by a solid-phase RIA involving antidigoxin antibodies and by a radioreceptor assay (RRA) involving human placenta Na+/K(+)-ATPase. The mean (SD) EDLF concentrations as measured by RIA were 35.6 (19.4) ng of dig...
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We describe the optimization and validation of a clinically feasible radioreceptor assay to detect endogenous digitalis-like factor(s) (EDLF) in human plasma and urine. The assay is based on the competitive replacement of 125I-labeled digoxin on human placenta membranes by ligands present in sample extracts. Digoxin and ouabain were used as calibrators. We also describe simple and effective met...
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A spectrophotometric method using benzoyl arginine ethyl ester (BAEE) is described for the assay of serum and plasma trypsin-like esterase activity. The method was used to find activities in serum and plasma (anticoagulated with oxalate and heparin) from 12 healthy males at 3 different reaction pH’s. The effects of calcium, oxalate, heparin, soybean trypsin inhibitor, ovomucoid, and heat on thi...
متن کاملEndogenous Digitalis-like factors in hypothermic patients
1Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU School of Medicine, USA 2Tufts University School of Medicine, Baystate Medical Center, USA 3Fredericksburg Emergency Medical Alliance, USA 4Norwalk Hospital, Western Connecticut Health system, USA 5Department of Emergency Medicine, University of British Columbia, Canada 6College of Pharmacy and Health Scie...
متن کاملImmunoreactive digitalis - like in pre - eclampsia substance
An endogenous digitalis-like substance (DLS) may be involved in the pathogenesis of essential hypertension and pre-eclampsia. The digoxin levels in maternal and cord blood of 504 randomly selected patients were determined. Since none of the patients received digoxin, these levels indicated a crossreacting substance (immunoreactive DLS). DLS levels were significantly higher in the cord blood of ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1989
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)83247-1